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Clinical research in the field of glaucoma is Dr. Panarelli's primary focus. He has collaborated with several mentors to publish new surgical techniques, evaluate the clinical impact of landmark studies in our field, and compare outcomes of various types of traditional glaucoma procedures in both the adult and pediatric population. He also continues to be involved in the clinical trials of several new “MIGS” devices. Micro-invasive glaucoma surgeries (MIGS) are being more widely used not only by glaucoma specialists, but also comprehensive ophthalmologists, as these procedures are safer than traditional glaucoma surgeries, such as trabeculectomy and glaucoma drainage implants.  As the principal investigator for several new device trials (Xen Gel Stent, Allergan and InnFocus Microshunt, Santen), he has been fortunate to work on the FDA trials with many clinicians throughout the US and Europe.  They seek to provide evidence and quantification of effect as they determine the role each of these devices in the evolving glaucoma treatment algorithm.  The Xen Gel Stent has recently received FDA approval and the InnFocus Microshunt trial completed enrollment in 2017.  He continues to train residents, fellows, and other attendings to become proficient with these MIGS procedures.